We target cancer differently — through its sugars
Unlike proteins, glycans are not directly template-encoded. Their structures are shaped by glycosylation enzymes, cellular metabolism, and signaling. As cancer develops, these processes are reprogrammed, creating tumor-associated glycan patterns that can contribute to immune evasion, altered cell adhesion, and metastatic spread.
Conventional ADCs typically target a single cell-surface protein. Loss or downregulation of that protein can reduce target availability and contribute to treatment resistance.
Our antibodies recognize a tumor-associated glycan epitope presented across multiple protein carriers. This approach is designed to:
GlycoNex's core capability is discovering antibodies against tumor-associated carbohydrate antigens. These anti-glycan antibodies anchor a pipeline of ADCs, pro-antibody ADCs, and bispecific ADCs — led by GNX1021, now in Phase 1.
Explore the pipeline →Two biosimilar programs: SPD8 (denosumab biosimilar, Phase 3 complete), co-developed with Mitsubishi Gas Chemical; and SSR, a biosimilar for an autoimmune disease, developed in-house.
View biosimilars →Contract development and manufacturing from a 50 L + 200 L GMP antibody facility: cell-line development, upstream and downstream process development, scale-up, and technology transfer for external partners.
CDMO services →One of the most extensive collections of anti-glycan monoclonal antibodies — over 50 to date — accumulated through two decades of dedicated research.
Learn more →Antibody-drug conjugates that pair GlycoNex's anti-glycan antibodies with clinically validated linker technology, directed at tumor-associated carbohydrate antigens that distinguish malignant from healthy cells.
Learn more →In-house GMP-compliant antibody production for Phase 1 clinical supply and external CDMO partners.
Learn more →GlycoNex's denosumab biosimilar met its Phase 3 primary endpoint in Japan, confirming clinical comparability to the reference product.
Read →Japan's Pharmaceuticals and Medical Devices Agency has authorized first-in-human dosing for GlycoNex's lead glycan-targeted ADC in patients with refractory GI cancers.
Read →Strategic preclinical collaboration on a next-generation pro-antibody ADC, with Nippon Kayaku contributing payload chemistry expertise.
Read →Building on SPD8 manufacturing experience, GlycoNex extends its biosimilar portfolio toward a high-volume immunology target.
Read →GlycoNex is actively seeking global licensing and co-development partners across our Phase 1+ pipeline.
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